Checkpoint Inhibitors Side Effects

Fatigue weakness nausea confusion headache loss of appetite vision problems fever.

Checkpoint inhibitors side effects.

Occasional any grade toxicities in 5 20 of patients include fatigue headache arthralgia rash pruritus pneumonitis diarrhoea and or colitis hepatitis and endocrinopathies table 1. Since these drugs rev up your immune system they can cause a range of side effects including fatigue cough nausea loss of appetite rash and problems in your lungs kidneys intestines. Paying careful attention to potential symptoms is therefore crucial. Common side effects associated with currently approved checkpoint immunotherapies may include but are not limited to.

Fatigue rash colitis infusion related reactions diarrhea asthenia arthralgias constipation decreased appetite cough dyspnea headache insomnia nausea pain including in the abdomen back and musculoskeletal system peripheral edema pneumonitis radiation pneumonitis pruritus pyrexia vomiting and weight loss. On average symptoms appear around nine weeks after starting treatment and may include. Diarrhea pneumonitis inflammation in the lungs rashes and itchiness problems with some hormone levels kidney infections. Other immune checkpoint inhibitors are under clinical evaluation.

Checkpoint inhibitor associated neurological side effects are rare but potentially life threatening. He says he figures these are just normal side effects of his medication. Common side effects of immune checkpoint inhibitors include. However immune checkpoint blockade can lead to the breaking of immune self tolerance thereby inducing a novel syndrome of autoimmune autoinflammatory side effects designated as immune related adverse events mainly including rash colitis hepatitis and endocrinopathies.

Mp inflammatory reactions involving the skin and the gastrointestinal tract are among the most common adverse events seen with checkpoint inhibitors.